| 咳喘穴位贴片体外透皮速率和体外释放规律研究 |
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| 引用本文： | 杨立平,;邓桂明,;杨广民.咳喘穴位贴片体外透皮速率和体外释放规律研究[J].中国药房,2009(18):1372-1374. |
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| 作者姓名： | 杨立平 ;邓桂明 ;杨广民 |
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| 作者单位： | [1]湖南省肿瘤医院,长沙市410013; [2]湖南中医药大学第一附属医院,长沙市410007 |
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| 基金项目： | 湖南省教育厅科学研究项目（05C371） |
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| 摘 要： | 目的:研究咳喘穴位贴片体外透皮速率和体外释放规律。方法:采用高效液相色谱法测定透皮接受液和释放液中指标成分盐酸麻黄碱的浓度,计算其渗透速率和体外释药速率。结果:麻黄碱以6.4679μg.cm-2.h-1/2的速率恒速渗透,其体外释药速率为21.382μg.cm-2.h-1/2,其释放过程符合Higuchi方程。结论:咳喘穴位贴片可研制为皮肤限速型的骨架控释系统。
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| 关 键 词： | 咳喘穴位贴片 透皮吸收 麻黄碱 |
Determination of in Vitro Percutaneous Rate of Kechuan Xuewei Patch and Its in Vitro Release Profile |
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| Institution: | YANG Li-ping,DENG Gui-ming, YANG Guang-min(Hunan Provincial Tumor Hospital,Changsha 410013,China;The First Affiliated Hospital of Hunan University of Traditional Chi nese Medicine, Changsha 410007, China) |
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| Abstract: | OBJECTIVE： To study the determination method vitro drug release profile. METHODS： The content of ephedrine of the percutaneous rate of Kechuan xuewei patch and its in hydrochloride（an index composition） in percutaneous reception fluid and release fluid were determined by HPLC, and the percutaneous penetration rate and the in vitro drug release rate were computed. RESULT： Ephedrine permeated at a constant rate of 6.467 9 μg · cm^-2·h^1/2 and the in vitro drug release rate was 21.382 μg·cm^-2. h^-1/2, fitting Higuchi equation. CONCLUSION： Kechuan xuewei patch can be prepared as controlled release matrix system of skin permeation rate- limited type. |
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| Keywords: | Kechuan xuewei patch Percutaneous absorption Ephedrine |
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