| 双环醇对利福平大鼠体内药动学的影响 |
| |
| 引用本文： | 黄淑萍,张洁,吴狄. 双环醇对利福平大鼠体内药动学的影响[J]. 中国药房, 2009, 0(19): 1466-1467 |
| |
| 作者姓名： | 黄淑萍 张洁 吴狄 |
| |
| 作者单位： | 天津市海河医院,天津市300350 |
| |
| 摘 要： | 目的:研究双环醇对利福平血药浓度及药动学的影响。方法:12只Wistar大鼠随机分为利福平(对照)组和双环醇+利福平(实验)组共2组,双环醇与利福平的剂量分别为15.85、63.4mg.kg-1,每天1次,连续给药4d。在第4天给药前和给药后0.25、0.5、1、1.5、2、4、6、8、12、24h取血,应用高效液相色谱法测定2组利福平的血药浓度,并计算药动学参数。结果:2组各时间点利福平血药浓度及药动学参数之间比较均无显著性差异(P>0.05)。结论:双环醇与利福平合用于大鼠体内后对利福平药动学无显著影响。
|
| 关 键 词： | 利福平 双环醇 大鼠 血药浓度 药动学 |
Effect of Bicyclol on Pharmacokinetics of Rifampin in Rats |
| |
| HUANG Shu-ping,ZHANG Jie,WU Di. Effect of Bicyclol on Pharmacokinetics of Rifampin in Rats[J]. China Pharmacy, 2009, 0(19): 1466-1467 |
| |
| Authors: | HUANG Shu-ping ZHANG Jie WU Di |
| |
| Affiliation: | (Tianjin Haihe Hospital, Tianjin 300350, China) |
| |
| Abstract: | OBJECTIVE： To study the effect of bicyclol on serum concentration and pharmacokinetics of rifampin in rats. METHODS： Twelve Wistar rats were assigned to receive rifampin 63.4 mg · kg^-1 1 alone （control group）or in combination with bicyclol 15.85 mg· kg^- 1（trial group） q.d for 4 days. Plasma samples were obtained on day 4 before and after drug adminis- tration 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 12 and 24 h. Blood concentrations of rifampin of 2 groups were determined by HPLC and the pharmacokinetics parameters were evaluated as well. RESULTS： Rifampin showed no significant differences at different time point in its concentration and pharmacokinetic parameters （P 〉0.05） between in 2 groups. CONCLUSION： Used in combination with rifampin, bicyclol showed insignificant effect on the pharmacokinetics of rifampin in rats. |
| |
| Keywords: | Rifampin Bicyclol Rat Blood drug concentration Pharmacokinetics |
| 本文献已被 维普 等数据库收录！ |
|
