膳食维生素 C 与 2 型糖尿病的关系

目的：探讨膳食维生素C摄入量与2型糖尿病的关系。方法：从中南大学湘雅医院体检中心随机选取被体检人员5 168名为研究对象，根据不同维生素摄入水平分为5组，分别为第一五分位数组(Q1，n=1 033)、第二五分位数组(Q2，n=1 034)、第三五分位数组(Q3，n=1 034)、第四五分位数组(Q4，n=1 034)、第五五分位数组(Q5，n=1 033)；根据是否有2型糖尿病分为2型糖尿病组(n=502)和非2型糖尿病组(n=4 666)。测量空腹血糖、身高、体质量、血压等指标，利用食物频率调查问卷测量膳食维生素C摄入情况。运用方差分析、卡方检验、Mann-Whitney U检验以及logistic回归模型等统计学方法分析膳食维生素C与2型糖尿病的关系。结果：单因素分析结果显示：不同维生素C摄入水平组的能量摄入、运动量、膳食纤维摄入、是否服用营养制剂、是否饮酒、学历等方面，差异均有统计学意义(均P<0.05)；同时2型糖尿病组与非2型糖尿病组在年龄、性别、体质量指数、吸烟情况、维生素C摄入情况等方面，差异亦均有统计学意义(均P<0.05)。在校正年龄、性别、高血压患病情况、吸烟情况等相关因素后，以维生素C摄入水平的最低分类(≤63.26 mg/d)作为参照，最高分类(>154.78 mg/d)的OR(95%CI)为0.610(0.428~0.870)，维生素C摄入水平的高低与2型糖尿病之间呈负线性关系(r=−0.029，P<0.05)。结论：膳食维生素C摄入与2型糖尿病之间存在负相关。

Relationship between dietary vitamin C and Type 2 diabetes

Objective: To examine the correlation between dietary vitamin C intake and Type 2 diabetes.Methods: A total of 5 168 participants from Xiangya Hospital, Central South University were randomly selected. According to the vitamin C intake, the participants were divided into 5 groups:a Q1 group (n=1 033), a Q2 group (n=1 034), a Q3 group (n=1 034), a Q4 group (n=1 034) anda Q5 group (n=1 033). Th ey were also divided into a Type 2 diabetes group (n=502) and a non-diabetes group (n=4 666). The height, weight, and blood pressure were measured, and vitamin C intake and other dairy consumption were evaluated using a food frequency questionnaire and fasting plasma glucose (FPG). Th e analysis of variance (ANOVA), Chi-square test, Mann-WhitneyU test and logistic regression model were used to analyze the relationship between dietary vitaminC and Type 2 diabetes.Results: The univariate analysis showed that there were significant differences in the vitamin Cconsumption in energy intake, activity level, dietary fiber intake, nutritional supplementation status,drinking or not drinking, education level among the different vitamin C intake groups (all P<0.05).There were also significant differences in age, sex, body mass index (BMI), smoking status andvitamin C intake between the Type 2 diabetes group and the non-diabetes group (all P<0.05). Afterthe adjustment for age, gender, hypertension, energy intake or smoking status, the multiple logisticregression model found that the multivariable adjusted OR was 0.610 (95% CI 0.428–0.870) forthe highest level of vitamin C intake (>154.78 mg/d) in comparison with the lowest level(≤63.26 mg/d). The results suggested that the vitamin C intake was inversely associated with theType 2 diabetes (r=−0.029, P<0.05).Conclusion: There is a significant negative correlation between the dietary vitamin C intake andthe risk of Type 2 diabetes.