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Significance of procalcitonin in the diagnosis of juvenile idiopathic arthritis.

??Abstracts?? Objective To study the relationship between procalcitonin ??PCT?? and the pathogenesis of juvenile idiopathic arthritis ??JIA??. Methods We tested the values of PCT and CRP of 150 JIA cases. To find the diagnostic value of PCT and CRP in JIA with bacterial infection??we compared the clinical value of PCT and that of CRP?? including sensitivity?? specificity??positive predictive value and negative predictive value. Besides?? we tested the level of PCT in various patterns of JIA. Results PCT value in cases of JIA with bacterial infection was ??3.56±0.84???? which was markedly higher than that in JIA cases with virus infection??0.05±0.01????P??0.05??and that in JIA disease activited without infection group??0.19±0.01????P??0.05??and that in control group .However?? there wasn’t significant difference between JIA cases with virus infection and control group. If we considered diagnostic positive threshold of JIA cases without virus infection as PCT≥0.5 μg/L??then its sensitivity?? specificity?? positive predictive value??negative predictive value ?? positive likelihood ratio and negative likelihood ratio were 76.2%??87.6%??50.0%??95.8%??6.14 and 0.27?? respectively. In 98.99% of the JIA activity without infection group PCT value was??0.5 μg/L??the median was 0.2 μg/L. In 66.7% of the JIA activity without infection group??PCT??0.1 μg/L. Conclusion Testing PCT value has significant role in diagnosing JIA with bacterial infection ?? and the prediction value is superior to CRP infection. It can be considered to recommend PCT??0.5 μg/L as the diagnosis of JIA infection in patients with critical value.