Protective effect of compression socks in a marathon runner with a genetic predisposition to thrombophilia due to Factor V Leiden |
| |
| Authors: | Amanda L Zaleski Linda S Pescatello Paul D Thompson Beth A Taylor |
| |
| Institution: | 1. Department of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA;2. Department of Kinesiology, University of Connecticut, Storrs, CT, USAamanda.zaleski@hhchealth.org;4. Department of Kinesiology, University of Connecticut, Storrs, CT, USA;5. Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA;6. Department of Kinesiology, University of Connecticut, Storrs, CT, USA |
| |
| Abstract: | Introduction. The present case study is an analysis of the effect of compression socks on hemostatic activation following a marathon in a female endurance athlete found to be heterozygous for the coagulation factor V (F5 1691 G>A Arg>Gln rs6025/560]) risk allele that predisposes one to a genetically inherited disorder of blood clotting, Factor V Leiden. Methods. Markers for coagulation and fibrinolysis were obtained 24 h prior to (PRE), immediately after (FINISH) and 24 h after (POST) completion of two marathons: the first in which the runner was not wearing compression socks, and the second in which the runner wore compression socks throughout the race. Results. Compression socks worn during a marathon appeared to lower the overall impact on hemostasis as well as clot formation in this particular athlete as evidenced by lower t-PA (–56%), TAT (–63%) and D-dimer (–30%). Conclusions. Hemostatic activation may be lower with the use of compression socks, and thus may be effective for preserving hemostasis in endurance athletes at risk. |
| |
| Keywords: | Marathon compression socks hemostasis Factor V Leiden |
|
|
