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Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases
Authors:Running Mark P  Lavy Meirav  Sternberg Hasana  Galichet Arnaud  Gruissem Wilhelm  Hake Sarah  Ori Naomi  Yalovsky Shaul
Affiliation:U.S. Department of Agriculture-Agricultural Research Service Plant Gene Expression Center, Albany, CA 94710, USA.
Abstract:Meristems require a myriad of intercellular signaling pathways for coordination of cell division within and between functional zones and clonal cell layers. This control of cell division ensures a constant availability of stem cells throughout the life span of the meristem while limiting overproliferation of meristematic cells and maintaining the meristem structure. We have undertaken a genetic screen to identify additional components of meristem signaling pathways. We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number. PLURIPETALA encodes the alpha-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have altered abscisic acid responses and overall much slower growth rate. plp is epistatic to mutations in the beta-subunit of farnesyltransferase and shows a synergistic interaction with clavata3 mutants. plp mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes.
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