| 原发性肾病综合征患者尿纤维结合蛋白测定的临床意义 |
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| 引用本文： | 刘虹,刘瑞洪,夏运成,许向青.原发性肾病综合征患者尿纤维结合蛋白测定的临床意义[J].中国现代医学杂志,2002,12(2):29-30. |
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| 作者姓名： | 刘虹 刘瑞洪 夏运成 许向青 |
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| 作者单位： | 中南大学湘雅二医院肾内科,长沙,410011 |
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| 摘 要： | 目的 :探讨尿纤维结合蛋白 (Fn)水平变化在原发性肾病综合征中的临床意义。方法 :采用ELISA法对2 8例原发性肾病综合征患者和 15例正常对照组进行尿Fn水平检测 ,比较分析其相互之间的差异及激素治疗前后的变化。结果 :原发性肾病综合征患者尿Fn水平为 42 3.46± 2 74.2 7ng/ml,明显高于正常对照组2 1.32± 15 .17ng/ml(P <0 .0 1) ,并且激素敏感型患者尿Fn水平治疗前为 44 9.2 9± 32 6 .79ng/ml,明显高于治疗后 180 .6 9± 71.0 9ng/ml(P <0 .0 1) .结论 :尿Fn化可作为原发性肾病综合征患者判断疗效及估计预后的重要指标之一。
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| 关 键 词： | 原发性肾病综合征 纤维结合蛋白 |
| 修稿时间： | 2001年5月22日 |
CLINICAL SIGNIFICANCE OF DETERMINING FIBRONECTION OF URINE IN PRIMARY NEPHROTIC SYNDROME |
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| Liu Hong,Liu Ruihong,Xia Yuncheng,et al..CLINICAL SIGNIFICANCE OF DETERMINING FIBRONECTION OF URINE IN PRIMARY NEPHROTIC SYNDROME[J].China Journal of Modern Medicine,2002,12(2):29-30. |
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| Authors: | Liu Hong Liu Ruihong Xia Yuncheng |
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| Institution: | Liu Hong,Liu Ruihong,Xia Yuncheng,et al. Division of Nephrology,The Second Affiliated Hospital,Xiangya Medical College,Central South University,Changsha 410011 |
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| Abstract: | Objective:To investigate the clinical significance of urine Fibronectin (Fn) levels in patients with primary nephrotic syndrome(PNS).Method:ELISA assay was employed to evaluate urine Fn levels of 28 PNS patients and 15 normal control people.Results:Urinary Fn level of PNS patients was higher than that of normal control group ( P <0.01).In addition,Urinary Fn level in PNS patients who are sensitive to predison before treatment was higher than that after treatment ( P <0.01).Conclusion:Urinary Fn level could estimate the curative effect and prognosis of primary nephrotic syndrome. |
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| Keywords: | Primary Nephrotic Syndrome Fibronectin |
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