| Ang-2和Tie-2在肝癌中表达及血管生成关系的研究 |
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| 引用本文： | 李金明,谢南,黄义华,温丽丽.Ang-2和Tie-2在肝癌中表达及血管生成关系的研究[J].上海医学检验杂志,2011(3). |
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| 作者姓名： | 李金明 谢南 黄义华 温丽丽 |
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| 作者单位： | 南昌市第九医院; |
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| 摘 要： | 目的流式细胞术检测血管生成素2(Ang-2)及酪氨酸激酶受体2(Tie-2)在肝癌中的表达,探讨其与CD105标记的血管表达量的关系,以期为研究肝癌发生、发展及血管生成提供理论支持。方法以112例肝细胞癌标本为研究对象,60例癌旁组织、60例正常肝组织作为对照,应用流式细胞术分别检测Ang-2、Tie-2和CD105的表达,分析其在不同临床病理特征之间的意义及相互关系。结果 Ang-2、Tie-2和CD105在肝癌中的表达均明显高于癌旁组织和正常肝组织,Ang-2、Tie-2和CD105在不同肿瘤直径、不同临床分期、不同甲胎蛋白(AFP)值及有无转移患者中比较,差异有统计学意义,肝癌中Ang-2、Tie-2和CD105的表达呈正相关。结论 Ang-2和Tie-2与肝癌的发生、发展有密切关系,Ang-2和Tie-2参与CD105表达的血管生成,联合检测Ang-2、Tie-2和CD105可能有助于肝癌患者预后判断。
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| 关 键 词： | 血管生成素2 酪氨酸激酶受体2 CD105 肝癌 血管生成 流式细胞术TheexpressionsandangiogenesisstudyofAng-2andTie-2inhepatocellularcarcinomaLIJinming XIENan HUANGYihua WENLili.(TheNinthHospitalofNanchangCity JiangxiNanchang330003 China) |
The expressions and angiogenesis study of Ang-2 and Tie-2 in hepatocellular carcinoma |
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| LI Jinming,XIE Nan,HUANG Yihua,WEN Lili..The expressions and angiogenesis study of Ang-2 and Tie-2 in hepatocellular carcinoma[J].Shanghai Journal of Medical Laboratory Sciences,2011(3). |
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| Authors: | LI Jinming XIE Nan HUANG Yihua WEN Lili |
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| Institution: | LI Jinming,XIE Nan,HUANG Yihua,WEN Lili.(The Ninth Hospital of Nanchang City,Jiangxi Nanchang 330003,China) |
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| Abstract: | Objective To investigate the expressions of angiopoietin-2(Ang-2) and tyrosine kinase receptor-2(Tie-2) in hepatocellular carcinoma by flow cytometry,and investigate the relationship with CD105 in pathogenesis,development and angiogenesis.Methods 112 samples of hepatocellular carcinoma tissue were enrolled as experimental group.60 samples of tumor-adjacent tissues and 60 samples of normal hepatic tissues were enrolled as control group.The expressions and relationship of Ang-2,Tie-2 and CD105 were analyzed i... |
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| Keywords: | Angiopoietin-2 Tyrosine kinase receptor-2 CD105 Hepatocellular carcinoma Angiogenesis Flow cytometry |
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