布托菲诺显著抑制全麻诱导时芬太尼诱发的咳嗽

 目的 评价在麻醉诱导前预注布托菲诺对全麻诱导时芬太尼诱发咳嗽的抑制效应。方法 本试验为随机双盲研究。160例患者随机分为2组（每组80例）：麻醉诱导前预注布托菲诺组或等量生理盐水组（对照组）。观察外周静脉快速注射3 μg/kg芬太尼（3 s内）所诱发的咳嗽发生情况以及实验过程中的血流动力学变化即心率（HR）和平均动脉压（MAP）。结果 布托菲诺组仅有2位患者出现轻中度咳嗽（2.5%）,而生理盐水组则有26位（32.5%）患者出现不同程度的咳嗽,其中轻度为5例（6.25%）,中度为14例（17.5%）,重度为7例（8.75%）。与对照组相比,诱导前预注布托菲诺不影响插管前HR和MAP,但可以降低气管插管后HR和MAP的升高。结论 布托菲诺显著降低全麻诱导时注射3 μg/kg芬太尼所诱发的咳嗽反应。

Butorphanol significantly suppresses fentanyl-induced cough during general anesthesia induction

Objective To evaluate the effects of pre-induction butorphanol administration on fentanyl-induced cough during anesthesia induction. Methods This was a random,double-blind study. One hundred and sixty elective surgical patients were equally and randomly assigned to one of the following groups in which butorphnol or equal volume normal saline (control) was injected through peripheral cannula 1 minute prior to intravenous administration of 3 μg/kg fentanyl in 3 seconds. The grade of cough and hemodynamics during the procedure were recorded. Results Only 2 (2.50%) patients had mild to moderate cough in pre-treatment butorphanol group, while 23 (28.75%) patients in control group coughed after giving fentanyl intravenously, in which there were 5 mild cases (6.25%), 14 moderate (17.5%), and 7 severe (8.75%). Compared with the control group, pre-induction butorphanol did not influenced heart rate(HR) and mean arterial pressure (MAP) before tracheal intubation, but significantly suppressed increase of HR and MAP caused by intubation. Conclusions Butorphanol pre-treatment significantly suppresses 3 μg/kg fentanyl-induced cough during anesthesia induction.