| CXCL16基因多态性与C反应蛋白的相关性研究 |
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| 引用本文： | 王克迪,刘志忠,王瑞珉,王雅杰,张国军,苏建荣,康熙雄.CXCL16基因多态性与C反应蛋白的相关性研究[J].上海医学检验杂志,2011(1). |
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| 作者姓名： | 王克迪 刘志忠 王瑞珉 王雅杰 张国军 苏建荣 康熙雄 |
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| 作者单位： | 首都医科大学附属北京天坛医院实验诊断中心;首都医科大学附属北京友谊医院检验科; |
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| 基金项目： | “十一五”863重点项目“心脑血管预警和早期诊断芯片”(2006AA020706) |
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| 摘 要： | 目的探讨健康人群趋化因子CXC配体16(CXCL16)基因多态性与血清CXCL16、C反应蛋白(CRP)水平的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测204名健康体检者CXCL16基因A181V多态性,同时分别应用酶联免疫吸附试验(ELISA)和免疫比浊法检测血清CXCL16和高敏CRP(hs-CRP)水平,并进行统计学分析。结果 AA基因型血清hs-CRP水平明显高于GG、GA基因型(P=0.01);多元线性回归显示A等位基因是高hs-CRP水平的独立危险因素(OR=1.25,95%CI:1.08~2.59,P=0.021);以血清hs-CRP水平中位数(0.91 mg/L)为界定值分为2组,AA基因型和A等位基因频率在hs-CRP>0.91 mg/L组中显著升高(P=0.008,0.036);而血清CXCL16水平与其基因型间差异无统计学意义(P>0.05)。结论 CXCL16基因A181V位点基因多态性与血清hs-CRP水平相关,A等位基因可能参与机体炎症反应的发生、发展。
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| 关 键 词： | 趋化因子CXC配体16 基因多态性 C反应蛋白 炎症反应 |
Research on the association between CXCL16 gene polymorphism and C reactive protein levels |
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| WANG Kedi,LIU Zhizhong,WANG Ruimin,WANG Yajie,ZHANG Guojun,SU Jianrong,KANG Xixiong..Research on the association between CXCL16 gene polymorphism and C reactive protein levels[J].Shanghai Journal of Medical Laboratory Sciences,2011(1). |
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| Authors: | WANG Kedi LIU Zhizhong WANG Ruimin WANG Yajie ZHANG Guojun SU Jianrong KANG Xixiong |
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| Institution: | WANG Kedi1,LIU Zhizhong2,WANG Ruimin2,WANG Yajie2,ZHANG Guojun2,SU Jianrong1,KANG Xixiong1.(1.Department of Clinical Laboratory,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China,2.Department of Clinical Laboratory,Beijing Friendship Hospital Affiliated to Capital Medical University,China) |
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| Abstract: | Objective To investigate the association of serum chemokine CXC ligand 16(CXCL16)and C reactive protein(CRP) levels with CXCL16 gene polymorphism in healthy subjects.Methods The polymorphisms of CXCL16 gene A181V were detected in 204 healthy subjects by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Enzyme-linked immunosorbent assay(ELISA) and particle-enhanced immunonephelometry were used to detect serum CXCL16 and high sensitive CRP(hs-CRP) levels respectively,and the results... |
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| Keywords: | Chemokine CXC ligand 16 Gene polymorphism C reactive protein Inflammatory response |
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