肥胖人群脂联素、抵抗素和胰岛素抵抗水平的研究 |
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引用本文: | 周强,杨静,罗淼珊,周芸,吴晓蔓,吕嘉春.肥胖人群脂联素、抵抗素和胰岛素抵抗水平的研究[J].上海医学检验杂志,2011(1). |
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作者姓名: | 周强 杨静 罗淼珊 周芸 吴晓蔓 吕嘉春 |
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作者单位: | 广州医学院第二附属医院检验科;广州医学院基础学院; |
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基金项目: | 广州市医药卫生科技项目(2005-YB-211) |
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摘 要: | 目的探讨肥胖患者血清脂联素、抵抗素和胰岛素抵抗水平的变化及意义。方法分别测定106例肥胖者和107名健康对照者的体重指数(BMI)、腰围、臀围、空腹胰岛素、空腹血糖、血脂、脂联素和抵抗素水平,计算胰岛素抵抗指数(HOMA-IRI)。结果肥胖者的体重指数(BMI)、体脂分布百分比(BF)、HOMA-IRI、抵抗素、脂联素、总胆固醇(TC)、载脂蛋白B(apo B)与健康对照组比较,差异均有统计学意义(P<0.01、P<0.05)。脂联素和抵抗素均与BMI、BF和HOMA-IRI呈正相关(脂联素:相关系数(r)分别为0.439、0.236、0.398,P均<0.01;抵抗素:r分别为0.296(P<0.01)、0.175(P<0.05)、0.827(P<0.01)],抵抗素与腰臀比(WHR)呈正相关(r=0.169,P<0.05)。结论脂联素能较好地预测BMI和HOMA-IRI,抵抗素能较好地预测BMI。脂联素与抵抗素水平的变化可能导致肥胖和胰岛素抵抗,在向糖尿病的发生发展过程中起了一定作用。
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关 键 词: | 脂联素 抵抗素 胰岛素抵抗 肥胖 |
Investigation of serum adiponectin,resistin and insulin resistance levels in the obese people |
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Abstract: | Objective To investigate the levels of serum adiponectin,resistin and insulin resistance levels of the obese people in Guangzhou area.Methods The body mass index(BMI),waist line,hip circumference,fasting insulin,fasting glucose,blood lipids,adiponectin and resistin levels were determined in 106 obese subjects and 107 healthy controls respectively,and the homeostasis model assessment-insulin resistance index(HOMA-IRI) was calculated.Results There was statistical significance of BMI,body fat percentage(BF),HO... |
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Keywords: | Adiponectin Resistin Insulin resistance Obesity |
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