| 白介素-22在慢性代谢性疾病中的研究进展 |
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| 引用本文： | 焦新峰,鲁翔,刘正霞. 白介素-22在慢性代谢性疾病中的研究进展[J]. 中华老年多器官疾病杂志, 2020, 0(11): 877-880 |
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| 作者姓名： | 焦新峰 鲁翔 刘正霞 |
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| 作者单位： | 南京医科大学第二附属医院中心实验室,南京医科大学衰老与相关疾病研究重点实验室,南京 210011,南京医科大学第二附属医院中心实验室,南京医科大学衰老与相关疾病研究重点实验室,南京 210011,南京医科大学第二附属医院中心实验室,南京医科大学衰老与相关疾病研究重点实验室,南京 210011 |
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| 基金项目： | 国家自然科学基金(81300999；81970374；81770440) |
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| 摘 要： | 目的 白介素-22(IL-22)是IL-10细胞因子家族成员,可以由多种免疫细胞分泌。IL-22受体(IL-22R)主要在非造血源性内皮细胞和基质细胞中表达,IL-22通过与IL-22R结合在黏膜屏障防御、组织修复、上皮细胞存活和增殖中发挥重要作用。IL-22的表达与多种代谢性疾病密切相关,是近年来代谢领域研究的热点。本文就IL-22在脂肪性肝病、肥胖、糖尿病等慢性代谢性疾病中的研究进展进行综述。
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| 关 键 词： | 白介素-22 代谢性疾病 脂肪性肝病 肥胖 糖尿病 |
| 收稿时间： | 2019-12-14 |
Research progress of interleukin-22 in chronic metabolic diseases |
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| Affiliation: | Central Laboratory of Second Affiliated Hospital of Nanjing Medical University, Key Laboratory of Aging and Related Diseases of Nanjing Medical University, Nanjing 210011, China,Central Laboratory of Second Affiliated Hospital of Nanjing Medical University, Key Laboratory of Aging and Related Diseases of Nanjing Medical University, Nanjing 210011, China and Central Laboratory of Second Affiliated Hospital of Nanjing Medical University, Key Laboratory of Aging and Related Diseases of Nanjing Medical University, Nanjing 210011, China |
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| Abstract: | Interleukin-22 (IL-22) , a member of the IL-10 cytokine family, is secreted by a variety of immune cells. Its receptor (IL-22R) is mainly expressed in non-hematopoietic endothelial cells and stromal cells. IL-22 plays important roles in mucosal barrier defense, tissue repair, epithelial cell survival and proliferation by binding to its receptor. The expression of IL-22 is closely associated with various metabolic diseases, and has become a hot topic in the field of metabolism in recent years. This article reviews the research progress of IL-22 in fatty liver disease, obesity, diabetes and other chronic metabolic diseases. |
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| Keywords: | interleukin-22 metabolic diseases fatty liver disease obesity diabetes mellitus This work was supported by the National Natural Science Foundation of China |
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