乙型肝炎母婴传播的初步研究

对59例HBsAg携带者母亲及其新生儿和44例HBsAg阴性母亲及其薪生儿作前瞻性研究以了解乙型肝炎对婴儿的感染。采血时间为分娩后0-1、3、6、12,18与30个月。用RPHA检测HBsAg。59例阳性母亲之婴儿中29例(49.15%)查出HBsAg。而44例阴性母亲之婴儿仅3例(6.82%)出现抗原(P<0.001),婴儿阳转的机率与其母亲之HBsAg滴度呈明显正相关(r=0.85, P<0.01). 13例HBeAg阳性母亲中12例之婴儿出现HBsAg,而46例e抗原阴性母亲之婴儿抗原阳转者仅17例(P< 0.01)。分娩后,HBsAg持续阳性的母亲的婴儿的抗原阳转率(64.7%)明显高于分娩后抗原转阴之母亲的婴儿(28%) (P<0.01)。

Study on Infection of Hepatitis B from Mother to Baby

A Study on the infection of newborn babies by HBV was carried out, 59 HBsAg carrier mothers and their babies had been followed up for 30 months since parturition.44 HBsAg negative mothers and their babies were studied simultaneously as control.Serum samples were taken from mothers and newborns immediately after delivery and 1, 3, 6, 12, 18 and 30 months later. The presence of HBsAg in sera was detected by RPHA.29(49.15%) of 59 HBsAg positive mother''s babies and 3(6.82%) of 44 negative mother''s became HBsAg positive during the observing period.The difference between the two groups is significant (P<0.001).The seroconversion possibility in babies was positively correlated with their mother''s HBsAg titer (r=0.85, P<0.01). When mothers were HBsAg positive, the possibility for their children to become HBsAg positive was greater than that of HBsAg negative ones. 25 carrier mothers became HBsAg negative after delivery, 7(28%) of their children gained HBsAg, while 22 (64.7%) of the 34 persistent carrier mother''s babies became HBsAg positive.