唾液传播乙型肝炎流行病学意义的研究

对71例乙型肝炎病人、33例HBsAg携带者、4例HBsAg阴性肝炎病人和正常健康人进行了唾液HBsAg、抗-HBs和抗-HBc的检测。结果表明，从乙型肝炎病人和HBsAg携带者的唾液中查出HBsAg（49.30%、39.39%）、抗-HBs（7.04%、6.06%）和抗-HBc（38.03%、27.27%）。并对4份HBsAg阳性唾液标本进行免疫电镜检查，其中2份标本可见直径20毫微米的成堆HBsAg颗粒。
为探讨唾液传播乙型肝炎的流行病学意义，我们采用前瞻性调查方法，经一年暴露期限，比较唾液HBsAg阳性组、阴性组以及健康对照组HBV感染率，结果提示，唾液传播乙型肝炎的作用并不十分明显。

Role of Saliva in the Transmission of Hepatitis B

Saliva samples from 71 patients with hepatitis B, 33 HBsAg carriers, 4 HBsAg-negative hepatitis patients and 21 healthy people were tested for HBsAg, anti-HBs and anti-HBc. The results showed the positive rates in type B hepatitis patients and HBsAg carriers. With HBsAg, were 49.30% and 39.39%, anti-HBs 7.04% and 6.06%, anti-HBc 38.03% and 27.27% respectively. Four HBsAg-positive saliva samples Were examined by means of immune electron microscopy, among which two were found to have 20 nm-diameter HBsAg aggregated particles. To study the epidemiologic importance of saliva as a possible vehicle of transmitting type B hepatitis, we also carried out a follow-up study to compare the infection rates among HBsAg positive saliva group, HBsAg negative saliva group and healthy control group. After one year of exposure, the result showed that saliva did not play an important role in the transmission of type B hepatitis.