北豆根抗炎镇痛作用的实验研究

目的探讨北豆根提取物的抗炎镇痛作用，为新药开发和指导临床用药提供依据。方法按不同工艺制备北豆根水煎液和流浸膏。采用二甲苯致小鼠耳肿胀模型和醋酸扭体实验研究北豆根不同提取物的抗炎镇痛作用。结果与空白组比较，北豆根水煎液和流浸膏低剂量均能明显减轻小鼠耳炎性肿胀（P〈0．05），显示良好的抗炎作用；均明显减少小鼠扭体次数（P〈0．01），且扭体反应抑制率均大于50％，表明两个提取物在低剂量的镇痛作用显著。结论北豆根水煎液和流浸膏低剂量均具明显的抗炎镇痛效果，且作用强于中、高剂量组。

Research of Anti-inflammatory and Analgesic Effect of rhizoma of Menispermum dauricum

Objective To evaluate the anti-inflammatory and analgesic effect of rhizoma of Menispermum dauricum DC. Methods The liquid decoctum and extract of rhizoma of M. dauricum were obtained through different extract techniques. The mice auricular swelling test and wrenching body test induced by acetic acid were conducted. Results Compared with control group, the low dose group of the liquid decoerum and extract significantly inhibited the inflammatory reaction induced by dimethyl benzene （P〈0.05）, which showed the favorable anti-inflammatory effects of rhizoma of M. dauricum. Compared with control group, both the low dose group of the liquid decocturn and extract obviously decreased the wrenching times of the mice （P〈0.01）. The inhibition ratios of wrenching in two low dose groups were over 50%, which indicated that rhizoma of M. dauricum had remarkable analgesic effect. Conclusion The rhizoma of M. dauricum has remarkable anti-inflammatory and analgesic effect, and the low dose groups of liquid decocrum and extract have better effect than high and middle dose groups.