Thermal influence on the lymphocytic response of cancer patients.

A variation was noted between normal subjects and cancer patients in the response of their lymphocytes to different antigens. Raising the temperature from 37 degrees C to 40 degrees C aided in improving lymphocytic activity to the antigenic stimulation. The heat response was more noticeable in normal subjects than in cancer patients, which suggests that immunotherapy should be initiated early in patients with malignant disease before there is systemic involvement from an increasing tumor burden.