Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family |
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| Authors: | Y. Ichigotani S. Matsuda K. Machida K. Oshima T. Iwamoto K. Yamaki T. Hayakawa M. Hamaguchi |
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| Affiliation: | (1) Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan Tel. +81-52-744-2463; Fax +81-52-735-8167 e-mail: smatsuda@med.nagoya-u.ac.jp, JP;(2) Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan, JP;(3) Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan, JP |
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| Abstract: | A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-β, suggesting that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906. Received: August 11, 2000 / Accepted: September 21, 2000 |
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| Keywords: | SIRP SHPS-1 Glycoprotein Chromosome 20p13 RH mapping |
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