标准型白细胞分化抗原44（CD44s ）鼻息肉发病过程中作用的初步研究

目的：研究CD44s 在鼻息肉中的表达及与鼻息肉发病的关系。方法：收集鼻息肉组织20例、正常下鼻甲粘膜组织15例(对照组)。HE 染色观察组织中炎症细胞浸润和上皮细胞受损情况；免疫组织化学染色观察CD44s 和EGF 的表达。结果：①鼻息肉粘膜上皮细胞、血管内皮细胞和基质炎症细胞CD44s表达（0.24±0.07，0.28±0.05，0.36±0.08）较下鼻甲粘膜（0.11±0.02，0.13±0.03，0.22±0.04）显著升高(P＜　0.05）；②鼻息肉组织中血管内皮细胞CD44s 蛋白表达和浸润Eos数目正相关(r=0.56，P＜0.05）；③EGF 在鼻息肉上皮表达（0.22±0.05）高于下鼻甲粘膜上皮（0.08±0.02），差异具有统计学意义(P＜0.05）。结论：促进炎症细胞浸润、上皮损伤修复及疝出固有层的上皮化过程中，CD44s 可能扮有重要的角色。

Effects of CD44s on the pathogenesis of nasal polyps

Objective: To investigate the expression of CD44s in the nasal polyps and its role in pathogenesis of nasalpolyps. Methods: The polypus tissue from twenty cases of nasal polyps and inferior turbinate mucosa from fifteen healthy adults were collected. Immunohistochemical staining for CD44s and EGF protein, and HE staining for the nasal polyps and inferior turbinate mucosa were performed. Results:①The expression of CD44s protein in epithelium, vascular endothelial cells and inflammatory cells were 0.24±0.07，0.28±0.05，0.36±0.08 in nasal polyps and 0.11±0.02，0.13±0.03，0.22±0.04 in inferior turbinate mucosa respectively(P＜0.05). ②The number of Eos in nasal polyps was associated with CD44s protein in vascular endothelial cells (r=0.56,P＜0.05). ③ The expression of EGF protein in nasal polyps was higher than that in inferior turbinate (P＜0.05）. Conclusions: CD44s may play an important role in facilitating the transmigration of CD44s＋ inflammatory cell and the epithelialization after epithelial damage.