生脉注射液对急性心肌梗塞缺血心肌的保护作用

目的：探讨生脉注射液对急性心肌梗塞（AMI）缺血心肌的保护作用。 方法：采用化学分光比色法分析检测48例AMI患者血清超氧化物歧化酶（SOD）及丙二醛（MDA）的动态变化，对随机分为应用生脉注射液治疗组26例、未应用生脉注射液治疗组22例与健康对照组24例的检测结果进行对比分析。 结果：两组AMI患者入院后即刻血清中SOD水平较健康对照组明显降低，MDA水平则明显增高（P<0.01）；随治疗时间延长,应用生脉注射液组患者血清SOD水平逐渐增高，MDA水平逐渐下降，未应用生脉注射液组患者血清中SOD及MDA水平与应用生脉注射液组变化趋势虽相同，但其血清检测含量却有明显差异（P<0.01）。 结论：生脉注射液通过对抗氧自由基和脂质过氧化，对AMI所致的缺血心肌起到一定的保护作用。

Protective effects of Shengmai injection on ischemic myocardium in patients with acute myocardial infarction

Objective To observe the protective effects of Shengmai injection on ischemic myocardium in patients with acute myocardial infarction (AMI). Methods Forty-eight AMI patients were randomly divided into Shengmai injection treatment group (n=26) and non-Shengmai injection treatment group (n=22), and 24 normal healthy subjects were used as controls. The levels of MDA and SOD in serum were assayed with colorimetric methods. Results The levels of SOD in all AMI patients were obviously lower than that in normal healthy sujects before therapy, and the levels of MDA were significantly increased (P<0.01); as the time went on, the level of SOD was increased gradually in Shengmai injection treatment group, and MDA level was decreased gradually. Although the levels of MDA and SOD in non-Shengmai injection treatment group had the same trends with the Shengmai injection treatment group, but there was marked difference of the serum content between the two groups (P<0.01). Conclusion With the effects of anti-oxygen-derived free radicals and anti-lipid peroxidation, Shengmai injection has protective effects on the ischemic myocardium in patients with AMI.