亚砷酸注射液治疗慢性粒细胞白血病疗效分析

为了评估亚砷酸注射液治疗成人慢性粒细胞性白血病（CML）的疗效,对温州医学院附属第三医院2002年1月～2005年12月住院的成人慢性粒细胞性白血病患者26例,采用亚砷酸注射液进行治疗,10mL/d,加入5%葡萄糖溶液500mL内缓慢静滴,用药时间28～35d。其中初治14例,难治或复发12例。26例患者中,完全缓解（CR）14例（53.9%）,部分缓解（PR）8例（30.7%）,无效（NR）4例（15.4%）,总缓解率（有效率）为84.6%。由此可见,亚砷酸注射液为治疗慢性粒细胞白血病一种有效药物,且毒副反应较轻,患者可耐受。

Study of sodium arsenite in treatment of adult chronic myelocytic leukemia:a report of 26 cases

The objective of this study was to estimate the effect of sodium arsenite in the treatment of adult chronic myelocytic leukemia(CML). Twenty-six inpatients diagnosed as chronic myeloid leukemia from January 2002 to December 2005 were treated with sodium aresenite, and 14 had not been treated previously,(untreated) while 12 were relapsing or resistant to previous treatment. The complete response (CR) rate among 26 was 53.9%,while the partial response(PR) rate was 30.7% and non-response(NR) rate was 15.4%.The total response rate was 84.6%. In conclusion, sodiunn arsenite (As2O3) is effective in the treatment of chronic myeloid leukemia and its side-effects are mild and well tolerant.