大剂量甲钴胺对糖尿病患者心率变异性影响的评价

目的：评价应用大剂量甲钴胺对糖尿病患者心率变异性的影响。方法：收集糖尿病患者64例，分为治疗组和对照组，治疗组患者静脉注射甲钴胺1mg，每天2次，连用2周后改为口服0．5mg，每天3次。总疗程为4周。运用24h动态心电图检测所有患者在治疗前后心率变异性指标的变化，明确甲钴胺治疗糖尿病心脏自主神经病变的疗效。结果：治疗组心率变异性各项指标治疗4周后较治疗前有显著提高，自主神经症状明显好转，与对照组比有显著统计学意义（P〈0．01）。结论：甲钴胺治疗糖尿病心脏自主神经病变的疗效显著，可以改善患者的心率变异性。

Evaluation about Effects of Methycobal on Heart Rate Variability

Aim： To evaluate the effects of methycobal on heart rate variability（HRV） in diabetes. Methods： 64 patients were assigned to receive 1 mg methycobal bid iv for two weeks then 0.5 mg po rid. The total treatment lasted for four weeks. The change of the heart rate variability parameters of all patients was detected using 24-hour DCG （dynamic electrocardiogram）, and the efficacy of methycobal on HRV in diabetics with cardiac autonomic neuropathy （CAN） was investigated. Results： In the treatment group, HRV parameters had a significant improvement after four week treatment. CAN was improved significantly, and there were significances as compared with the control group. Conclusion： Methycobal is effective for CAN in the patients with diabetes and it can improve the HRV of the patients.