蒽环类药物心脏毒性机制及其监测进展

以阿霉素(多柔比星)、表阿霉素(表柔比星)和吡喃阿霉素(吡柔比星)为代表的蒽环类抗癌药作为最有效的化疗药之一,目前在临床上广泛应用于白血病、乳腺癌、肺癌、淋巴瘤等多种恶性肿瘤,具有抗瘤谱广、临床疗效高等显著特点,是多种化疗方案的核心药物。然而,剂量依赖性不可逆的心脏毒性严重限制了其使用。现就国内外近年对蒽环类药物心脏毒性的发病机制、监测等方面的进展予以综述。

Research Advance in Mechanism and Monitor of the Cardiac Toxicity of Anthracyclines

As the best effective chemotherapy,anthracycline anti-cancer drug is represented by Adriamycin(doxorubicin),epirubicin(epirubicin)and pirarubicin(THP),widely used in the clinical treatment of Leukemia,breast cancer,lung cancer,lymphoma and other malignancies,characterized by broad spectrum and good clinical efficacy,and become the core of a variety of chemotherapy drugs.However,the development of irreversible cardiotoxicity has limited their use.This article summarized the research progress in pathogenesis,monitoring of anthracycline -induced cardiotoxicity.