支气管哮喘患儿血清ECP和IgE检测的临床意义

目的探讨血清嗜酸粒细胞阳离子蛋白(ECP)和免疫球蛋白(IgE)在哮喘患儿发病中的临床意义。方法对60例患儿和20例健康儿血清进行了ECP及IgE检测。结果哮喘发作期ECP显著高于稳定期、缓解期及健康对照组,缓解期患儿血清ECP水平明显下降接近正常对照组;IgE发作期明显高于缓解期和健康对照组,但缓解期与稳定期差异无显著性,仍明显高于正常对照组。患儿发作血清ECP、IgE间无明显相关。结论血清ECP水平能更准确反映哮喘患儿嗜酸粒细胞活化状态和气道炎症变化,是诊断、判断病情及指导治疗的可靠指标。

Clinical significance of serum ECP and IgE in children with bronchial asthma

Objective To explore the clinical significance of serum eosinophil cationic protein(ECP)and immunoglobuline E(IgE) in children with asthma.Methods ECP and IgE in serum of children with asthma were examined by the immuno-CAP system and ELISA respectively.In the meanwhile,20 healthy children were also detected as control.Results The concentration of ECP of asthmatic children in paroxysmal phase was obviously higher than that in stable and alleviated phase and the control group.The concentration of IgE of asthmatic children in paroxysmal phase was also significantly higher than that in alleviated phase and the control group but had no difference with that in stable phase(P>0.05).Conclusion These results suggest that the level of serum ECP can reflect the inflammation in the bronchial tube and the activated state of eosinocyte more sensitively than IgE.