青少年正常高值血压患者靶器官损伤相关性分析

目的探讨青少年正常高值血压患者靶器官损伤情况及其影响因素。方法选取2008年～2010年首都医科大学附属北京安贞医院急诊科、体检中心就诊青少年患者,分为正常高值血压患者组(n=32)和正常对照组(n=45)。比较各组左心室质量指数(LVMI)、左室舒张末期内径(LVDd)、舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、颈动脉内膜-中层厚度(IMT)、肾小球滤过率(GFR)。结果与正常对照组相比,正常高值血压组患者血压明显升高,正常高值血压组患者肥胖更多,存在更多高血压家族史(P<0.05);两组LVDd、IVST、LVPWT、颈动脉IMT、GFR无显著性差异(P>0.05)。与正常对照组相比,正常高值血压组患者LVMI增加,E/A比值降低(P<0.05)。结论相比较动脉硬化及肾功能改变,正常高值血压青少年心脏靶器官损害更加突出,且多发生于肥胖青少年人群中。

Analysis of Target Organ Damage in Youth with Pre-hypertension

Objective To explore target organ damage in the youth with pre-hypertension.Methods 77 consecutive youth visiting our institution form 2008 to 2010 were divided into pre-hypertension group(n=32) and control group(n=45).The relevance of left ventricular mass index(LVMI),left ventricular end-diastolic diameter(LVDd),interventricular septum thickness(IVST),left ventricular posterior wall thickness(LVPWT),carotid plaque intima-media thickness(IMT) and glomerular filtration rate(GFR) were compared.Results The blood pressure of pre-hypertension group was higher than that of control group,and the pre-hypertension group followed higher family hypertension history(P<0.05).There was no difference in LVDd,IVST,LVPWT,carotid plaque IMT and GFR between 2 groups(P>0.05).Compared with the control group,LVMI increased(P<0.05) and the E/A ratio decreased(P<0.05).Conclusion Target organ damage in pre-hypertension youth is salient compared with changes in renal function and damage of arteriosclerosis,and heart damage is more often occurred in the obese youth with pre-hypertension.