美托洛尔联合卡托普利治疗慢性心力衰竭临床疗效观察

目的观察美托洛尔联合卡托普利治疗慢性心力衰竭的临床疗效。方法90例患者随机分为治疗组与对照组，每组45例，对照组给予心衰的常规治疗（卡托普利、利尿剂、洋地黄制剂等），治疗组在对照组基础上联用美托洛尔治疗，观察12周，观察治疗前后心功能改善情况，包括左室舒张末内经（LVEDD）、左室收缩末内径（LVESD）和左室射血分数（LVEF），并随访6月。结果（1）治疗组总有效率91．11％；对照组总有效率71．11％，两组比较有显著性差异（P〈O．05）；（2）治疗组治疗前后及与对照组治疗后比较，LVEDD和LVESD显著减小（P〈0．05），LVEF显著提高（P〈0．05）；（3）随访6月，对照组死亡2例，治疗组无一人死亡；对照组再住院率为33．33％，治疗组为11．11％。结论美托洛尔与卡托普利联合治疗慢性心力衰竭，能显著提高疗效，改善症状及提高生活质量，减少猝死率及再住院率。

Clinical Curative Effect of Metoprolol Combined with Captopril in Treating the Patients with Chronic Congestive Heart Failure

Objective To observe the clinical curative effect of metoprolol combined with captopril in treating the patients with chronic congestive heart failure. Methods 90 cases were randomly divided into 2 groups ： treatment group and control group, 45 eases in each ; captopril, diuretic, digitalis and some other drugs were given to the patients in control group and treatment group, and in addition, metoprolol was applied in combination to the patients in treatment group; the observation lasted from 12 weeks on the improvement of heart function before and after treatment, including LVEDD, LVESD and LVEF; follow - up covered 6 months. Results The total effective rate of treatment group was 91.11% while that of control group was 71.11% ; the comparison between the 2 groups was of significant difference （ P 〈 0. 05 ） ; LVEDD and LVESD of both groups after treatment reduced obviously compared with those before treatment （ P 〈 O. 05 ） but LVEF raised a lot （ P 〈 0. 05） ; follow- up for 6 months revealed no death occurred in treatment group but 2 in control group; the re -hospitalization rate in control group was 33. 33% while that in treatment group was 11.11%. Conclusions Metoprolol combined with eaptopril can raise obviously the curative effect, improve symptoms and life quality, it can also reduce the sudden death rate and re -hospitalization rate.