TPX2在细胞有丝分裂中的作用及与肿瘤发生的关系

 【摘要】　TPX2蛋白是脊椎动物一个新的纺锤体成分家族，作为纺锤体成分的一种微管相关蛋白，弥散分布在S期和G2期细胞的核心，在细胞有丝分裂纺锤体形成过程中发挥重要作用。TPX2在多种恶性肿瘤中存在过表达，导致细胞中心体异常扩增、异倍体形成以及细胞恶性转化，并与肿瘤的生物学行为有关。阻断其表达可抑制肿瘤细胞的生长，有望成为肿瘤治疗的候选靶点。文章对TPX2的结构、功能、细胞周期中的表达水平和激酶活性变化的分子机制等方面的研究进展进行了综述。

Roles of TPX2 in cell mitotic and the relation with tumorigenesis

【Abstract】　TPX2 (targeting protein for Xklp2) is a microtubule-associated protein in a new family of vertebrate spindle pole components. TPX2 is diffusely distributed all over the nucleus during the cell cycle phases S and G2 and play important roles in mitotic spindle formation. TPX2 over expression was found in a variety of malignant tumors, that are asssociated with the centrosome amplification, aneuploidy, cell transfor－mation and the biological behavior of tumor. Blocking the expression of TPX2 can inhibit the growth of tumor cells. TPX2 may serve as a new candidate target for tumor therapy. The study progress of its structure and function, expression levels in cell cycle, molecular mechanism etc. was reviewed.