| 均匀设计法优化复方熊果苷凝胶的基质处方 |
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| 引用本文： | 苏华,冷静,殷芳芳,任海祥,王曙东.均匀设计法优化复方熊果苷凝胶的基质处方[J].中国药师,2012(11):1592-1595. |
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| 作者姓名： | 苏华 冷静 殷芳芳 任海祥 王曙东 |
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| 作者单位： | 南京军区南京总医院制剂科;南京军区南京总医院药品科 |
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| 摘 要： | 目的:优化祛斑外用制剂复方熊果苷凝胶的基质处方。方法:以卡波姆-940、甘油+丙二醇、三乙醇胺、氮酮加入量为可变因素,以复方熊果苷凝胶的性状均匀性、润滑性、黏附力、保湿率、pH为考察指标,通过均匀设计试验优化处方。结果:最佳基质处方为:卡波姆-940为0.8%,三乙醇胺为0.8%,甘油+丙二醇为40%,氮酮为1%。结论:复方熊果苷凝胶制备工艺简便、外观细腻均匀、润滑性黏附力好、符合临床应用要求。
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| 关 键 词： | 复方熊果苷凝胶 均匀设计 卡波姆-940 |
| 收稿时间： | 2012/6/26 0:00:00 |
| 修稿时间： | 2012/8/13 0:00:00 |
Optimization of Base Formula for Compound Arbutin Gels by Uniform Design |
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| Su Hu,Leng Jing,Yin Fangfang,Ren Haixiang and Wang Shudong.Optimization of Base Formula for Compound Arbutin Gels by Uniform Design[J].China Pharmacist,2012(11):1592-1595. |
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| Authors: | Su Hu Leng Jing Yin Fangfang Ren Haixiang and Wang Shudong |
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| Institution: | 1(1.Department of Preparation Division,Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China;2.Department of Pharmaey,Nanjing General Hospital of Nanjing Military Command) |
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| Abstract: | ABSTRACT Objective: To optimize the base formula of compound arbutin gels.Method:The amounts of Carbopol 940,glycerol and propylene glycol,triethanolamine and Azone as the variable factors,and the homogeneity,lubricity,adhesive force,moisture capacity and pH value as the indices,the base formula was optimized by uniform design.Result:The optimum formula was established as follows: carbopol 940 of 0.8%, glycerol and propylene glycol of 40%,triethanolamine of 0.8% and Azone of 1%. The quality of compound arbutin gels was stable.Conclusion:Compound arbutin gels show promising quality for the clinical application with simple preparation process, homogeneous appearance and good adhesive force. |
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| Keywords: | Compound arbutin gels Uniform design Carbopol 940 |
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