首页 | 本学科首页   官方微博 | 高级检索  
检索        

新生儿先天性甲状腺功能低下症筛查及治疗
引用本文:殷会芳,杨宏莉.新生儿先天性甲状腺功能低下症筛查及治疗[J].中国优生与遗传杂志,2008,16(12):93-94.
作者姓名:殷会芳  杨宏莉
作者单位:[1]保定市妇幼保健院新生儿筛查室; [2]河北大学医学部生物教研组,071000
摘    要:目的了解保定市近几年新生儿先天性甲状腺功能低下症(congenital hypothyroidism,CH)的发病率,并对确诊患儿的治疗情况进行分析。方法以2005年1月~2008年7月间保定市区及部分县、乡出生的新生儿为对象,出生3天后,采集足跟血滴于S&903S型号滤纸上,采用时间分辨荧光免疫法(DELFIA),通过测定滤纸干血片中的促甲状腺素(thyroid—stimulating hormone,TSH)的含量进行先天性甲低筛查;电化学发光法测定血清中FT3、FT4、T3 T4和鸭H的含量进行确诊;口服左旋甲状腺素片(L—T4)给予治疗。初始剂量为8—10ug/kg·d,顿服,维持剂量以无用药过量临床症状且FT4在正常范围之上限为剂量标准,定期随访,进行体格、智能发育、骨龄生长发育情况及血清FT3、FT4、T3 T4和TSH含量的测定。结果2005年1月~2008年7月共筛查146219人,确诊先天性甲低44人,其中暂时性甲低2人,发病率为0.30‰(1/3333)。确诊患儿(赊3人到外院进行治疗,1人治疗过程中拒绝随访外)治疗1个月后,血清FT4恢复正常36人,50天内恢复正常4人,体格和智能发育均在正常范围内,骨龄发育基本正常。结论新生儿筛查是早发现先天性甲低的重要手段,而且早诊断,早治疗是预防患儿体格及智能严重受损的关键。

关 键 词:新生儿筛查  先天性甲状腺功能低下  发病率  治疗

Neonatal screening for congenital hypothyroidism and treatment in Baoding city
Institution:YIN Hui -fang. YANG Hong -li. (Ma- ternal and Child Hospital Neonatal Screening Center of Baoding City, 071000 )
Abstract:Objective: To explore the incidence of newborns with congenital hypothyroidism, CH in Baoding city in recent years and analyse treatment. Methods: Heel blood sample were dropped on s&903S type filter paper from neonate older than 3 days after birth in local hospital and sent to the center of Baoding city neonatal disease screaning in 7 - 10 days. TSH levels on dried blood sam- ples were measured by Time- resolved fluoroimmunoassay. (victor^1420 device made by Wallac company in Finland). FT3, FT4, T3 T4 and TSH levels in serum were tested by chemiluminesence. Infants with CH were treated with levothyroxine ( L - T4). Initial dosage was 8 - 10ug/kg · d one times a day, criterion of normal dosage was that FT4 was at upper limit. Infants were followed - up and tested physical, mental development and bone age regularly. Results: From January 2005 to July 2008, total 146219 newborns were screened and 44 cases were diagnosed as CH, including 2 cases temporary CH, the incidence of CH was 1 in 3333. One month after infants with CH were treated, FT4 levels in serum of 36 cases reduce to normal level and 4 cases in 50 days, growth and development of physical, mental and bone age were nearly normal. Conclusion : Neonatal screening was an important mean that could detect neonate with CH in early time, also timely diagnosis and treatment were playing a critical role on preventing neonatal physical and mental from heavely harm.
Keywords:Neonatal screening  Congenital hypothyroidism  Incidence  Treatment
本文献已被 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号