| HLA—DQB1基因与汉族天疱疮的相关性研究 |
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| 引用本文： | 周淑华,林麟,靳培英,叶顺章.HLA—DQB1基因与汉族天疱疮的相关性研究[J].中国麻风皮肤病杂志,2002,18(3):220-222. |
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| 作者姓名： | 周淑华 林麟 靳培英 叶顺章 |
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| 作者单位： | 1. 滨州医学院附属医院皮肤科,256603
2. 中国医学科学院皮肤病研究所,南京,210042 |
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| 摘 要： | 目的：探讨HLA－DQB1基因在天疱疮易感性中的作用。方法：用序列特异性引物－聚合物链反应（PCR－SSP）方法，对59例寻常型（PV）患者、37例红斑型天疱疮（PE）患者及53例正常对照者进行了HLA－DQB1等位基因的分型，并分析了DQB1基因在两组中的分布。结果与结论：与正常对照组比较，PV与PE患者组中HLA－DQB1*0302、DQB1*0503基因频率明显增高。本研究结果提示，HLA－DQB1*0302、DQB1*0503基因是我国汉族天疱疹易感性的标志。
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| 关 键 词： | 天疱疮 聚合酶链反应 序列特异性引物－聚合酶链反应 基因分型 HLA－DQB1＊0302 HLA－DQB1＊0503 HLA－DQB1基因 汉族 |
The association between HLA - DQB1 genes and pemphigus in Han Chinese in Jiagsu and Anhui Provinces |
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| Zhou Shuhua,Lin Lin,Jin Peiying,et al..The association between HLA - DQB1 genes and pemphigus in Han Chinese in Jiagsu and Anhui Provinces[J].China Journal of Leprosy and Skin Diseases,2002,18(3):220-222. |
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| Authors: | Zhou Shuhua Lin Lin Jin Peiying |
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| Institution: | Zhou Shuhua,Lin Lin,Jin Peiying,et al. Institute of Dermatology,Chinese Academy of Medical Sciences and Pekin Union Medical college,Nanjing,210042 |
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| Abstract: | Objective:To investigate the predisposing role of HLA-DQB1 genes in pemphigus vulgaris.Method:Polymerase chain reaction-specific sequence primers to type HLA-DQB1 sub-region were used in 59 patients with pemphigus vulagris (PV) and 37 patients with pemphigus erythematosus (PE) of Han nationality from Jiangsu and Anhui Provinces and 53 matched control subjects.Results and Conclusions: The results demonstrated that HLA-DQB1*0302, HLA-DQB1*0503 gene frequencies were significantly higher in PV and PE patients than those in controls. It is suggested that HLA-DQB1*0302 and HLA-DQB1*0503 are the susceptibility markers for PV and PE in Han Chinese. |
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| Keywords: | pemphigus PCR HLA-DQB1 |
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