| 唑类药物体外诱导白念珠菌耐药的初步研究 |
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| 引用本文： | 宋晓静,许冰.唑类药物体外诱导白念珠菌耐药的初步研究[J].临床皮肤科杂志,2003,32(10):575-576. |
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| 作者姓名： | 宋晓静 许冰 |
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| 作者单位： | 浙江大学医学院附属第一医院皮肤科,浙江,杭州,310003 |
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| 摘 要： | 目的：了解不同抑菌浓度的唑类药物体外诱导白念珠菌的耐药情况。方法：将质控株及敏感白念珠菌在含不同抑菌浓度的氟康唑(FCZ)、酮康唑(KCZ)、伊曲康唑(ICZ)的液体培养基中进行人工传代诱导耐药。结果：敏感白念珠菌在高浓度的唑类药物培养基中能诱导耐药，且为交叉耐药，而在低浓度中经传20代仍不能诱导耐药；诱导后的耐药菌株在无药物培养基中传代可恢复敏感性。结论：唑类药物能诱导耐药白念珠菌的产生，但与诱导药物的浓度有关，且为不稳定耐药。
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| 关 键 词： | 白念珠菌 唑类药物 耐药 |
| 文章编号： | 1000-4963(2003)10-0575-02 |
| 修稿时间： | 2003年2月9日 |
The primary study of the induction of resistance to azoles in Candida albicans in vitro |
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| SONG Xiao-jing,XU Bing.The primary study of the induction of resistance to azoles in Candida albicans in vitro[J].Journal of Clinical Dermatology,2003,32(10):575-576. |
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| Authors: | SONG Xiao-jing XU Bing |
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| Abstract: | Objective:To acquire the information about the resistance to azoles in Candida albicans.Methods:A total of5susceptible C.albicans were cultured in the liquid medium containing different azoles in different concentrations.MIC was deter-mined by the method of microdilution antifungal susceptibility testing.Results:In susceptible C.albicans the resistance and cross-resistance were induced in liquid culture only with high concentrations of azole drugs.The susceptibility to azoles could be recovered in these resistant C.albicans after several generation cultures in drug-free liquid medium.Conclusions:These results indicated that the resistance and cross-resistance to azoles could be induced in C.albicans,which are dependent on drug concentration and unstable. |
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| Keywords: | Candida albicans azoles drug resistance |
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