Thiopurines in inflammatory bowel disease revisited |
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Authors: | Florian Br Christian Sina Klaus Fellermann |
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Institution: | Medical Department 1,University Hospital Schleswig Holstein,23538 Lübeck,Germany |
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Abstract: | Although a great variety of new drugs have been introduced for the therapy of inflammatory bowel diseases so far, a definite cure of the disease is still out of scope. An anti-inflammatory approach to induce remission followed by maintenance therapy with immunosupressants is still the mainstay of therapy. Thiopurines comprising azathioprine and its active metabolite mercaptopurine as well as tioguanine, are widely used in the therapy of chronic active inflammatory bowel disease (IBD). Their steroid sparing potential and efficacy in remission maintenance are out of doubt. Unfortunately, untoward adverse events are frequently observed and may preclude further administration or be life threatening. This review will focus on new aspects of thiopurine therapy in IBD, its efficacy and safety. |
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Keywords: | Thiopurines Mercaptopurine Tioguanine Azathioprine Ulcerative colitis Crohn’s disease |
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