冠心病患者血清糖化蛋白与内源性分泌型晚期糖化终产物受体水平及意义

目的：测定冠心病患者血清糖化蛋白（GSP）和内源性分泌型糖化终末产物受体（esRAGE）水平，探讨GSP、es-RAGE水平及GSP／esRAGE比值对判断冠心病的存在及冠状动脉病变严重程度的价值.方法：入选患者135例，根据冠脉造影结果和有无糖尿病分为：单纯冠心病组（52例），冠心病合并糖尿病组（48例），正常对照组（35例），根据冠状动脉病变支数分为：单支病变组（24例），双支病变组（29例）和三支病变组（47例）。测定各组血清GSP和eaRAGE水平，计算GSP／esRAGE比值。结果：冠心病合并糖尿病组GSP水平和GSP／esRAGE比值显著高于单纯冠心病组（均P〈0．01）及对照组（均P〈0．011），单纯冠心病组显著高于对照组（P〈0．01）；冠心病合并糖尿病组esRAGE显著低千单纯冠心病组（P〈0．01）和对照组（P〈0.01），单纯冠心病组明显低于对照纽（P〈0.01）；GSP（rs=0.460，P〈0．01）、esRAGE（rs=-0，542，P〈0.001）、GSP／esRAGE比值（fs=0．536，P〈0．001）与冠状动脉病变支数显著相关。结论：血清GSP、esRAGE水平及GSP／esRAGE比值对评价血糖正常或糖尿病患者冠心病的存在和冠状动脉病变程度具有重要临床价值。

Serum Levels and Significance of Giycated Protein and Endogenous Secretory Receptor for Advanced Glycated end Products in Patients with Coronary Artery Disease

Objective:To investigate the clinical significance of serum levels of glycated protein (GSP),endogenous se- cretory receptor for advanced glycated end products (esRAGE)and GSP/esRAGE ratio in assessing the presence and severity of coronary artery disease(CAD) in patients with and without type 2 diabetes mellitus(T2DM).Methods:Serum levels of GSP and esRAGE were measured and GSP/esRAGE ratio was calculated in 48 patients with angiographic CAD and T2DM,52 with angiographic CAD only,and 35 controls.All patient...