Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation |
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| Authors: | Kiyoshi Morimoto Keiko Sato Soichiro Sato Norihito Yamada Toshiyuki Hayabara |
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| Affiliation: | aDepartment of Neuropsychiatry, Faculty of Medicine, Kagawa Medical University, Kagawa, Japan;bClinical Research Institute, National Minamiokayama Hospital, 4066 Hayashima-cho, Tsukubo-gun, 701-03, Japan;cDepartment of Neuropsychiatry, Okayama University Medical School, Okayama, Japan |
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| Abstract: | We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the dentate gyrus ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyrus were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4±7.1% of the control level, mean±SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP. |
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| Keywords: | Long-term potentiation Dentate gyrus Hippocampus Synapsin I mRNA |
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