| 曲美他嗪辅佐治疗冠心病合并慢性心力衰竭的临床疗效观察 |
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| 引用本文： | 钱 喆,周国宝,李俭春.曲美他嗪辅佐治疗冠心病合并慢性心力衰竭的临床疗效观察[J].药学与临床研究,2011,19(5):454-456. |
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| 作者姓名： | 钱 喆 周国宝 李俭春 |
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| 作者单位： | 1. 南京医科大学附属苏州医院,苏州,215001
2. 南京军区南京总医院,南京,210002 |
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| 摘 要： | 目的:观察曲美他嗪辅佐治疗冠心病合并慢性心力衰竭的临床疗效。方法:选择61例冠心病合并慢性心力衰竭的患者,随机分为曲美他嗪治疗组(30例)和对照组(31例)。曲美他嗪组在常规心衰治疗基础上加用曲美他嗪(20 mg,tid)。两组均连续治疗6个月。分析治疗前后心功能级别、左室射血分数(LVEF)及N-末端脑钠素前体(NT-ProBNP)的变化。结果:6个月后曲美他嗪组与对照组相比,心功能级别分别降低36.4%、30.2%(P<0.01),LVEF分别提高22.5%、13.0%(P<0.05),两组NT-ProBNP水平均较治疗前明显改善(P<0.05),分别降低49.6%、29.0%(P<0.05)。结论:在常规心衰治疗基础上加用曲美他嗪能明显提高疗效。
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| 关 键 词： | 冠心病 充血性心力衰竭 N-末端脑钠素前体 曲美他嗪 |
| 收稿时间： | 2011/5/5 0:00:00 |
| 修稿时间： | 2011/8/18 0:00:00 |
Clinical Evaluation of Trimetazidine in the Treatment of Coronary Arterial Disease with Chronic Heart Failure |
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| QIAN Zhe,ZHOU Guo-bao and LI Jian-chun.Clinical Evaluation of Trimetazidine in the Treatment of Coronary Arterial Disease with Chronic Heart Failure[J].Pharmacertical and Clinical Research,2011,19(5):454-456. |
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| Authors: | QIAN Zhe ZHOU Guo-bao and LI Jian-chun |
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| Institution: | QIAN Zhe1,ZHOU Guo-bao1,LI Jian-chun2 1Suzhou Hospital of Nanjing Medical University,Suzhou 215001,2General Hospital of Nanjing Command of PLA,Nanjing 210002,China |
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| Abstract: | Objective: To explore the therapeutic effects of trimetazidine(TMZ) in patients with coronary artery disease(ACD) and congestive heart failure(CHF).Methods: A total of 61 CAD patients with CHF were randomly divided into two groups: conventional therapy group and TMZ group(TMZ+conventional therapy),and treated for 6 months.All patients underwent two-dimensional echocardiography,the levels of plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP) were determined and the changes of left ventricular ejecti... |
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| Keywords: | Coronary artery disease Congestive heart failure N-terminal pro-B-type natriuretic peptide Trimetazidine |
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