|
|||||
|
|
Antifungal combination therapy in localized candidosis |
|
| Authors: | A Polak |
| Affiliation: | Fa. Hoffmann-La Roche Ltd., Basel, Switzerland. |
| Abstract: | A mouse model of localized candidosis in air-filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5-FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5-FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5-FC + Amph B was also tested against Candida albicans strains showing various degrees of 5-FC-resistance. A significant reduction in 5-FC-resistant mutants was seen after the treatment with the combination. |
| Keywords: | Candidosis mouse model combination therapy antifungal drugs amphotericin B flucytosine imidazoles triazoles fluconazole ICI 195,739 itraconazole ketoconazole resistance Candidose Mausmodell Kombinationstherapie Antimyzetika Amphotericin B Flucytosin Imidazole Triazole Fluconazol ICI 195,739 Itraconazol Ketoconazol Resistenz |