辛伐他汀对2型糖尿病高脂血症的疗效

目的:探讨辛伐他汀 20mg/d治疗 2型糖尿病高脂血症的疗效及安全性。方法:60例 2型糖尿病高脂血症患者随机分为2组,各30例。分别予辛伐他汀1片(每片 5mg或20mg)·qn,用药4wk。结果:辛伐他汀20mg/d组降低TC 33％,降低LDL-C 46％,降低TG 26％,升高 HDL-C21％,且降低TC/HDL-C 44％。组间比较,2组的血清TG、LDL-C降低幅度及 HDL-C上升幅度有显著性差异(P<0.01)TC 降低幅度无明显差异(P>0.05)。对血糖水平无不良影响。结论:20mg/d治疗2型糖尿病高脂血症患者安全、有效。

Clinical efficacy of simvastatin in treating hyperlipidemia in the type 2 diabetes

Objective:To evaluate the curative efficacy and safety of treating the type 2 diabetic hy-perlipidemia with simvastatin 20 mg/tablet. Methods: Sixty patients of type 2 diabetes hyperlipidemiawere divided randomly into 2 groups. Thirty patients separately were given simvastatin orally 5 mg/tablet(LDL) or 20 mg/tablet in evening for 4 wk. Results: Simvastatin 20 mg/tablet reduced serum total choles-terol(TC)33%, reduced low density lipoprotein (LDL)46%, reduced triglycerides (TG) 26%, rose highdensity lipoprotein(HDL)21%, and reduced TC/HDL-C 44%. Comparasion of 2 groups, area of reducedTG and LDL-C and area of rose HDL-C had remarkables differences(P<0.01), area of reduced TC hadno remarkable differences(P>05). It had no effect on blood glucoes. Conclusion: Simvastatin 20 mg/tablet is one of the safe and effective drugs to treat hyperlipidemia of the type 2 diabetes.