In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells |
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| Authors: | An Wouters Bea Pauwels Filip Lardon Greet GO Pattyn Hilde AJ Lambrechts Marc Baay Paul Meijnders Jan B Vermorken |
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| Affiliation: | (1) Laboratory of Cancer Research and Clinical Oncology, Department of Medical Oncology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium;(2) Department of Radiotherapy, University Radiotherapy Antwerp (URA), Lindendreef 1, 2020 Antwerp, Belgium |
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| Abstract: | Background Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first time, presents the triple combination of MTA, dFdC and irradiation using various treatment schedules. |
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