Association study between a polymorphism at the 3'-untranslated region of <Emphasis Type="Italic">CLOCK</Emphasis> gene and attention deficit hyperactivity disorder期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder

Authors:	Xiaohui Xu Gerome Breen Chih-Ken Chen Yu-Shu Huang Yu-Yu Wu Philip Asherson

Affiliation:	(1) MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK;(2) Department of Psychiatry, Chang Gung Memorial Hospital, Taiwan;(3) Chang Gung University School of Medicine, Taiwan;(4) Division of Mental Health & Drug Abuse Research, National Health Research Institutes, Taiwan

Abstract:	Background The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances. A recent study has reported that a polymorphism (rs1801260) at the 3'-untranslated region of the CLOCK gene is associated with adult ADHD.

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