慢性荨麻疹患者血清特异性IgE和T淋巴细胞检测

目的：分析慢性荨麻疹的致病因素以及细胞免疫功能的改变。方法：采用免疫印迹法体外半定量检测血清特异性IgE，采用流式细胞仪双色直接免疫荧光法分析T淋巴细胞亚群。结果：305例慢性荨麻疹患者中109例患者至少对一种过敏原呈阳性反应，阳性率为35．74％，57例健康献血员的特异性IgE检测全部为阴性，两组比较差别有统计学意义（X^2=-22．95，P〈0．05）。在18种常见变应原的检测中发现，户尘螨的阳性率最高，达13．77％，而且中重度过敏者（Ⅲ级以上）达4．92％。结论：慢性荨麻疹的病因复杂，部分患者是由于接触变应原引起的Ⅰ型变态反应，同时伴有T淋巴细胞免疫功能紊乱。

The Analysis of Specific IgE and T Lymphocyte in Chronic Urticaria

Objective: The Analysis of nosogenesis and immunocytic function in Chronic Urticaria. Methods: Immunoblot was used to test the serum sIgE. T Lymphocyte subspecies was tested by immediate immune fluorescence. Results: 35.74%(109/305) of patients were positive with specific IgE. Whereas 57 blood donators were negative entirely. There are statistially significant(P < 0.05) differences in the two groups. Positive ratio of Dermatophagoides pteronyssinus in 18 specises of allergen was the highest,13.77% and median or serious patients obtained 4.92%. Conclusion: The nosogenesis of Chronic Urticaria is complex. A part of patients are cased by type I allergy, accompanied by function disorder of T Lymphocyte.