中国人群吸烟与喉癌关系的Meta分析

目的综合评价中国人群吸烟与喉癌之间的关系及关联强度，为我国喉癌的防治策略提供依据。方法在CNKI、万方、维普、PubMed、ScienceDirect、SpringerLink、Wiley、ProQuest等数据库中系统检索截止2013年1月之前国内外发表的相关研究文献。所有文献检索、文献选取、文献信息的提取及文献质量评价均由两人独立进行。根据研究之间的异质性大小采用合适的方法来合并相关结果。结果纳入合格研究文献16篇，喉癌患者2730例，对照3224例。吸烟与喉癌发病关系的合并0尺值为4．08（95％CI：2．90—5．26；r=86．7％，P〈0．001）。很少吸烟者及经常吸烟者发生喉癌的OR值为分别为5．90（95％CI：3．05～11．41）及13．30（95％CI：8．03～22．03）。结合漏斗图的结果，尚不能认为目前纳入的研究存在发表偏倚（Egger，P=0．402；Begg，P=0．784）。结论在中国，吸烟会显著增加喉癌的发病风险，而且随着吸烟量的增加，喉癌的风险可能更高。

Meta-analysis on the relationship between smoking and the risk of laryngeal cancer among Chinese population

Objective To evaluate the relationship and the strength of association between smoking and the risk of laryngeal cancer among Chinese population, providing support for preventing laryngeal cancer in China. Methods A sys- tematic search of electronic databases （including CNKI, VIP, Wanfang, Pubmed, ScienceDirect, SpringerLink, Wiley, ProQuest） up to now was performed. Two reviewers independently conducted the literature search, study eligibility, data extraction and quality evaluation. Pooled odds ratio （OR） value and 95% CI value were calculated with suitable methods according to the heterogeneity among different studies. Results 16 studies involving 2730 cases of laryngeal cancer and 3224 controls were included in this review. The pooled OR between smoking and the risk of laryngeal cancer was 4.08 （95% CI： 2. 90 - 5.26 ; 12 = 86. 7%, P 〈 0. 001 ）. Re-analysis showed that the pooled ORs were 5.90 （95 % CI： 3.05 - 11.41 ） for seldom smokers and 13.30 （95% CI： 8.03 -22. 03） for frequent smokers respectively. Combined with the funnel plot, no significant publication bias is found among the included studies （ Egger, P = 0. 402 ; Begg, P = 0. 784）. Conclusion Smoking is significantly positively associated with increased risk of laryngeal cancer, and the risk increased as the dose of smoking increases.