Mania associated with ranitidine: a case report and review of literature |
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| Authors: | Audrey Mauran Tudi Goze Delphine Abadie Emmanuelle Bondon‐Guitton Pauline Chevrel Laurent Schmitt Jean‐Louis Montastruc François Montastruc |
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| Affiliation: | 1. Department of Medical and Clinical Pharmacology, Pharmacop?le Midi‐Pyrénées, Centre Midi‐Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France;2. Department of Psychiatry and Medical Psychology, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France;3. Department of Gastroenterology, Centre Hospitalier Universitaire, University of Toulouse, Toulouse, France |
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| Abstract: | H2 receptor antagonists can be associated with central adverse drug reactions (ADRs), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a ‘serious’ case of severe mania leading to hospitalization in a 42‐year‐old alcohol‐dependent man, 4 days after ranitidine introduction. Review of literature showed that this ‘very rare’ ADR occurs mainly in patients with predisposing factors: age, decrease in renal and/or hepatic function, polymedication, alcohol. Knowledge of this ADR can be particularly important for these drugs widely used as self‐medication. |
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| Keywords: | H2 receptor antagonists mania psychiatric adverse drug reactions ranitidine self‐medication |
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