| 国人无综合征性耳聋患者的线粒体基因组7445^A→G突变263 … |
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| 引用本文： | 刘玉和,戚豫.国人无综合征性耳聋患者的线粒体基因组7445^A→G突变263 …[J].临床耳鼻咽喉头颈外科杂志,2000,14(4):177-178. |
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| 作者姓名： | 刘玉和 戚豫 |
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| 摘 要： |
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| 关 键 词： | 无综合征性耳聋 线粒体DNA DNA突变分析 |
Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population] |
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| Y H Liu,X M Ke,Y Qi,H B Xu,Z P Gu,X C Liu,J F Liu.Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population][J].Journal of Clinical Otorhinolaryngology,2000,14(4):177-178. |
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| Authors: | Y H Liu X M Ke Y Qi H B Xu Z P Gu X C Liu J F Liu |
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| Institution: | First Hospital, Beijing Medical University, Beijing 100034. |
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| Abstract: | OBJECTIVE: To study the Mitochondrial DNA 7445A-->G mutation in nonsyndromic deafness patients in Chinese population. METHOD: Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to screen the mitochondrial DNA 7445A-->G mutation among 128 nonsyndromic deafness individuals from 32 pedigrees, 135 sporadic nonsyndromic deafness patients and 100 normal subjects. RESULT: The 7445A-->G mutation did not appear in the experiment. CONCLUSION: Incidence of the mitochondrial 7445A-->G mutation was lower than that of mtDNA 1555A-->G mutation in nonsyndromic deafness patients in China. |
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