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二甲基甲酰胺对接触工人肝功能的影响
引用本文:钱亚玲,徐承敏,朱丽瑾,项橘香,柴剑荣,阮征,张幸. 二甲基甲酰胺对接触工人肝功能的影响[J]. 中华劳动卫生职业病杂志, 2007, 25(2): 80-83
作者姓名:钱亚玲  徐承敏  朱丽瑾  项橘香  柴剑荣  阮征  张幸
作者单位:1. 310013,杭州,浙江省医学科学院卫生学研究所
2. 杭州市余杭区疾病预防控制中心
基金项目:浙江省自然科学基金(Y204075)
摘    要:目的探讨二甲基甲酰胺(DMF)接触浓度、饮酒量及其他因素对DMF接触工人肝功能的影响。方法根据工厂前2年车间空气的监测数据,将DMF分为对照组、低接触组及高接触组。采用问卷调查了解各组研究对象的基本情况及饮酒习惯,采集血样测定肝功能。结果低接触组和高接触组血清丙氨酸转氨酶(ALT)及γ-谷氨酰转肽酶(γ-GT)水平明显高于对照组,高接触组血清天冬氨酸转氨酶(AST)水平高于低接触组;高接触组肝脏指数(Liver index)明显高于对照组和低接触组。多元线性回归分析表明ALT、γ-GT、肝脏指数与接触DMF及体重指数(BMI)相关,ALT还与甘油三酯(TRIG)相关,AST只与工人的饮酒量相关。在肝功能异常者中,有86.7%的AST/ALT比值<1。结论DMF能影响接触工人肝功能,肥胖及饮酒量有一定的协同作用。肝脏指数和AST/ALT比值可作为肝损伤评价和筛选指标。

关 键 词:二甲基甲酰胺  职业性接触  肝功能测试
修稿时间:2006-06-22

Abnormal liver function associated with occupational exposure to N, N-dimethylformamide insynthetic leathers works
QIAN Ya-ling,XU Cheng-min,ZHU Li-jin,XIAN Ju-xiang,CHAI Jian-rong,RUAN Zheng,ZHANG Xing. Abnormal liver function associated with occupational exposure to N, N-dimethylformamide insynthetic leathers works[J]. Chinese journal of industrial hygiene and occupational diseases, 2007, 25(2): 80-83
Authors:QIAN Ya-ling  XU Cheng-min  ZHU Li-jin  XIAN Ju-xiang  CHAI Jian-rong  RUAN Zheng  ZHANG Xing
Affiliation:Zhejiang A cademy of Medical Sciences, Hangzhou 310013, China
Abstract:OBJECTIVE: To investigate the hepatotoxic effects of N, N-dimethylformamide (DMF) in the workers of a synthetic leathers factory, and the effects on liver function of covariates such as alcohol consumption and other factors. METHODS: The workers were classified into three groups (low, high and the control) by the concentration of DMF in workplace which was determined in the past two years. A questionnaire was drawn up for relevant demographic characteristics and other factors influencing liver function. The bloods were collected for laboratory test which included parameters especially relevant to the liver (ALT AST and gamma GT). RESULTS: Low and high-exposure groups were significantly associated with elevated ALT and gamma GT, and high-exposure group was significantly associated with elevated Liver index. Modeling by stepwise regression analysis demonstrated that high concentration of DMF and BMI were associated with and elevated ALT, gamma GT and Liver index, besides DMF and BMI, the elevation of ALT was also associated with high TRIG. AST was only associated with alcohol consumption. The AST/ALT ration < 1 was present in 86.7% of the exposure workers of liver function abnormal. CONCLUSION: DMF can cause liver function alternations even if air concentration of DMF was below PC-TWA. Besides the levels of DMF exposure, obesity (BMI) and alcohol consumption are covariates alternating liver function. Liver index can be a parameter for assessment liver function, and the AST/ALT ration < 1 may serve as markers of risk in health screening programs.
Keywords:N  N-dimethylformamide  Occupational exposure  Liver function test
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