四分子交联体家族成员9在滋养细胞中的表达及其意义

目的 探讨四分子交联体家族成员9(TM4SF9)蛋白在滋养细胞巾的表达及意义.方法 应用免疫组化方法检测TM4SF9蛋白在早孕绒毛,葡萄胎,侵蚀性葡萄胎和绒毛膜癌中的表达情况.结果 (1)在早孕绒毛,TM4SF9蛋白仅表达于细胞滋养层细胞,而在合体滋养层细胞则未见表达;(2)TM4SF9蛋白在早孕绒毛、葡萄胎和侵蚀性葡萄胎,绒癌中的表达依次增强,强阳性率分别为0,10%,36.4%,100%,差异有统计学意义(P<0.001).结论 TM4SF9蛋白的表达可能与滋养细胞的侵袭行为有关,TM4SF9在滋养细胞肿瘤的侵袭中有一定作用.

Expression of TM4SF9 in human trophoblasts

OBJECTIVE: To investigate the expression of TM4SF9 in the villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissue. METHODS: Immunohistochemistry was used to detect the expression of TM4SF9 in normal villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissues. RESULTS: TM4SF9 was expressed in the cytotroblasts but not in the syncytiotrophoblast of normal villi. The intensity of TM4SF9 expression increased in the order of normal villi, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma, with strong positivity rates of 0, 10%, 36.4% and 100%, respectively, showing significant differences between the samples (P<0.001). CONCLUSION: TM4SF9 expression in the trophoblasts may relate to their invasiveness and play an important role in the metastasis of trophoblastic tumor.