乙肝免疫球蛋白和乙肝疫苗联合免疫阻断母婴传播效果观察

目的]了解乙肝免疫球蛋白（HBIG）乙肝疫苗联合阻断母婴传播的效果，为制定阻断乙肝母婴传播对策提供科学依据。方法]2006年，在武进区选择200例血清HBsAg阳性孕妇，随机分为2组，实验组孕妇怀孕14周起每周注射HBIG200IU，临产时加强一剂；婴儿出生后注射1剂，同时按0、1、6个月接种10μg重组酵母乙肝疫苗。对照组孕妇孕产期不注射HBIG；婴儿出生时注射HBIG200IU，同样程序接种乙肝疫苗。2组婴儿均采取母乳喂养。结果]1岁时婴儿HBsAg阳性率，实验组为8．00％，对照组为19．00％（P〈0．05）；1岁时婴儿抗-HBs阳性率，实验组为26．00％，对照组为14．00％（P〈0．05）。结论]对HBsAg阳性孕妇在孕中、后期注射HBIG可以提高乙肝母婴阻断效果。

Observation on The Effect of Blocking Mother to Child Transmission or Hepatitis B Virus with Method of Hepatitis B Immune Globulin Combined Hepatitis B Vaccine

Objective]To survey the effect of blocking mother to child transmission of Hepatitis B virus with method of Hepatitis B immune globulin combined Hepatitis B vaccine,Methods]The 200 pregnant women with HBs-positive were chose in Wujin district in 2006. They were randomly arranged in the experimental group and the control one. The formers were injected HBIG200IU weekly since the 14th week during their pregnancy, and re-injected in parturient period. Their infants were injected recombinant yeast-derived hepatitis B vaccine at the 0,1st, 6th month; The later was not injected With HBIG. Their infants were injected with HBIG200IU immediately after were born,then injected recombinant yeast-derived hepatitis B vaccine 10UG at the 0,1st, 6th month. Newborn breast-feeding are taken in two infant groups. Results]The HBsAg positive rate of the infants aged 1 year in the experimental group was 8% ,and 19% in the control group（ P 〈0.05）. The anti- H Bs positive rate in the former group was 26%, and 14.00%in another one （ P〈0.05 ）.Conclusion] The results indicated that the effect of blocking mother to child transmission of Hepatitis B virus was improved when the pregnant women with HBs-positive injected HBIG during intra and post pregnancy.