Fluoride-induced chronic renal failure |
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| Authors: | O Lantz M H Jouvin M C De Vernejoul P Druet |
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| Affiliation: | 1. From the Service de Néphrologie, Inserm U 28, Hôpital Broussais, Paris and Inserm U 18, Hôpital Lariboisiere, Paris;1. C.U.R.E. University Centre for Liver Disease Research and Treatment, Institute of Internal Medicine, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy;2. Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy;3. Department of General Surgery, University of Foggia, Foggia, Italy;1. Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran;2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Pediatric Hematology, Oncology and Bone Marrow Transplant Unit, HCG Cancer Center, Bengaluru, Karnataka, India;2. Pediatric Hematology, Oncology and Blood & Marrow Transplantation, Mazumdar Shaw Medical Centre, Narayana Health City, Bengaluru, 560099, India;3. MCGM – Comprehensive Thalassemia Care, Pediatric Hematology-Oncology & Bone Marrow Transplantation Centre, Borivali (E), Mumbai, 400 066, India;4. Pediatric Oncology & Health Sciences, Tata Memorial Centre, HBNI, Mumbai, 400012, India;5. Pediatric Hematology Oncology and Bone Marrow Transplant, Apollo Cancer Institute, Chennai, India;6. Hematology-Oncology & BMT Services, QURE LLP Hematology-Oncology Center, Ahmedabad, Gujarat, 380060, India;7. Pediatric Hemato-Oncology and Bone Marrow Transplantation, Manipal Hospital, Jaipur, Rajasthan, 302013, India;8. Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta the Medicity Hospital, Gurgaon, Haryana, 122001, India;1. Department of Biotechnology, Oriental Institute of Science and Technology (Vidyasagar University), Dewandighi, Burdwan 02, India;2. Central Institute of Freshwater Aquaculture, Rahara, India;3. Drug Development Diagnostics and Biotechnology, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India |
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| Abstract: | Renal fluoride toxicity in human beings is difficult to assess in the literature. Although experimental studies and research on methoxyflurane toxicity have shown frank renal damage, observations of renal insufficiency related to chronic fluoride exposure are scarce. We report a case of fluoride intoxication related to potomania of Vichy water, a highly mineralized water containing 8.5 mg/L of fluoride. Features of fluoride osteosclerosis were prominent and end-stage renal failure was present. The young age of the patient, the long duration of high fluoride intake, and the absence of other cause of renal insufficiency suggest a causal relationship between fluoride intoxication and renal failure. |
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