Évaluation de l’activité antiasthmatique et antitussive de Combretum molle, plante médicinale de la pharmacopée ivoirienne |
| |
Authors: | D. Yeo J. D. N’Guessan T. Sea Y. A. Coulibaly A. J. Djaman N. A. Tako J. C. Yavo F. Guede-Guina |
| |
Affiliation: | 1. Laboratoire de pharmacodynamie biochimique, UFR biosciences, université de Cocody-Abidjan, Cocody-Abidjan, Afrique 3. Laboratoire de biotechnologie, UFR biosciences, université de Cocody-Abidjan, Cocody-Abidjan, Afrique 2. Laboratoire de neurosciences, UFR biosciences, université de Cocody-Abidjan, Cocody-Abidjan, Afrique 4. Laboratoire de pharmacologie clinique, UFR des sciences médicales, université de Cocody-Abidjan, Cocody-Abidjan, Afrique
|
| |
Abstract: | In this work, we studied the inhibitory effects of Combretum molle extract on respiratory disturbances and coughs. Injection of 3.33 mg/kg and 7.14 mg/kg of Combretum molle had no effect on a rabbit’s breathing. Injection of acetylcholine (0.2 ml; 714.10?3 mg/kg) induced a percentage estimated at ?100%. But a combined injection of acetylcholine and increasing doses of Combretum molle reduced this percentage from ?100% to ?20 ± 0.5%. We also studied the inhibitory effects of the crude extract on coughs. Guinea pigs which were not treated produced 10.25 ± 0.95 in 10 minutes. But treating the guinea-pigs with 3 mg/kg of crude extract resulted in 8.25 ± 0.45 coughs for 10 min. With 30 mg/kg, however, coughing was reduced to 4.5 ± 0.25. We could therefore conclude that the extract presents some inhibitory effects on coughing and bronchial contraction induced by acetylcholine. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|