Quantification of flow volume with a new digital three-dimensional color Doppler flow approach: an in vitro study. |
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Authors: | J Li X Li Y Mori R A Rusk J S Lee C H Davies I Hashimoto G O El-Sedfy X N Li D J Sahn |
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Affiliation: | Clinical Care Center for Congenital Heart Disease, Oregon Health Sciences University, Portland 97201-3098, USA. |
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Abstract: | OBJECTIVE: The quantification of flow stroke volume is important for evaluation of patients with cardiac dysfunction and cardiovascular disease. Three-dimensional digital color Doppler flow imaging allows the acquisition of flow data in an orientation approximately parallel to flow and analysis of the Doppler flow velocities perpendicular to flow (cross-sectional flow calculation). This in vitro study assessed the applicability of this method for quantifying cardiac output in a funnel-shaped tube model similar to mitral inflow or the left ventricular outflow tract. METHODS: A new digital three-dimensional color Doppler method was used to acquire Doppler flow information. Raw scan line data with digital velocity assignments were obtained on a conventional Doppler color flow imaging system with a 180 degrees rotating multiplanar transesophageal probe connected to a computer workstation. Nine stroke volumes (20-60 mL) with flow rates ranging from 1.5 to 5.28 L/min in a funnel-shaped pulsatile laminar flow model were studied. Three-dimensional flow rates were compared with standard-of-reference measurements of flow obtained from timed collection in a graduated cylinder and with an ultrasonic flow meter. RESULTS: Within the funnel tube, the flow volumes that were calculated from the first, second, and third depths and the average of all 3 depths correlated well with the actual flow rate (r = 0.97-0.99). Results from the middle and second levels and from the average of all 3 depths provided the closest fit to the actual flow rates (r = 0.99; y = 0.96x + 0.14; and r = 0.98; y = 1.14x - 0.43, respectively). CONCLUSIONS: Although a work in progress, this digital three-dimensional color Doppler flow measurement method is feasible, accurate, and simple, and it may offer in vivo evaluation of blood volume flow given a favorable orientation between the valve orifice and the scanning device. |
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