二甲亚砜对家兔内毒素性发热的影响

目的:观察二甲亚砜(DMSO)对家兔内毒素性发热的影响。方法:以健康封闭群新西兰兔为实验对象,随机分组。经耳缘静脉注射内毒素(ET)和DMSO,用WRY-B型微机热原测温仪测定家兔的结肠温度。结果:静脉注射ET引起家兔结肠温度双相性升高,其发热反应指数明显高于对照组。静脉注射ET10min前注射不同剂量DMSO组,家兔发热反应指数明显低于静脉注射内毒素组,并呈剂量依赖关系。静脉注射ET(0.4μg/mL,1mL/kg)10min后注射DMSO(60%,1mL/kg)组,发热反应指数同样明显低于静脉注射内毒素组。结论:DMSO明显抑制家兔内毒素性发热。

Effect of dimethyl sulfoxide on endotoxin -induced fever in rabbits

AIM:To investigate the effect of dimethyl sulfoxide on endotoxin -induced fever in rabbits. METHODS:Test substances were administered intravenously into a marginal ear vein. Temperature responses were measured using rectal thermistor probes. RESULTS:Endotoxin (0.4 μg/kg) stimulated a biphasic rise in colonic temperature. Pretreatment with dimethyl sulfoxide significantly attenuated the biphasic febrile response to endotoxin (0.4 μg/kg) of conscious rabbits in a dose-dependent manner. Rabbits treated with dimethyl sulfoxide 10 min after injection of endotoxin developed fever, which was significantly milder compared with rabbits treated with an equal volume of normal saline. No significant differences were found between thermal response index of rabbits injected with dimethyl sulfoxide and those with normal saline. CONCLUSION:Dimethyl sulfoxide inhibit endotoxin-induced fever in rabbits.