Endocrine and gastric secretory changes induced by increased intracranial pressure |
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| Authors: | J A O'Neill W Booth W DeWeese C M Johnson D G Kline F C Nance |
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| Affiliation: | 1. Nashville, Tennessee, USA;2. New Orleans, Louisiana, USA;1. Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA;1. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;2. Department of Chemistry, Yasuj University, Yasuj 75918-74831, Iran;3. Department of Pathology, Yasuj University of Medical Sciences, Yasuj, Iran;4. Social Determinants of Health Research Centre, Yasuj University of Medical Sciences, Yasuj, Iran;5. Department of Biotechnology and Microbial Nanotechnology, Dena Pathobiology Laboratory, Yasuj, Iran;1. School of Materials Science and Engineering, Southeast University, Jiangsu Key Laboratory of Construction Materials, Collaborative Innovation Center for Advanced Civil Engineering Materials, Nanjing 211189, China;2. Sobute New Materials Co., LTD, Nanjing 211103, China;1. School of Materials and Chemical Engineering, Xi’an Technological University, Xi’an 710021, China;2. State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China;1. CRIACIV-Department of Civil and Environmental Engineering, University of Florence, Florence, Italy;2. Department of Agriculture, Food, Environment and Forestry, University of Florence, Florence, Italy |
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| Abstract: | A chronic experimental preparation representing an intracranial lesion with increased intracranial pressure is described. Induction of a space-occupying lesion in the right frontoparietal cortical area resulted in hyposecretion of gastric acid and mucus, and an acute duodenal ulcer developed in one of eleven dogs. No evidence of hypothalamic or related structural lesions was noted. Chronic stress was indicated by persistent, marked elevations in plasma cortisol.It is suggested that with decreased renewal of gastric mucus, any level of acidity may be responsible for mucosal damage seen with the complication of intracranial pathology known as Cushing's ulcer. |
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